A poorly neutralizing IgG2a/c response elicited by a DNA vaccine protects mice against Japanese encephalitis virus.

@article{Chen2014APN,
  title={A poorly neutralizing IgG2a/c response elicited by a DNA vaccine protects mice against Japanese encephalitis virus.},
  author={Hsin-Wei Chen and Hui-Wen Huang and Hui-mei Hu and Han-Hsuan Chung and Szu-Hsien Wu and Pele Chong and M. H. Tao and C H Pan},
  journal={The Journal of general virology},
  year={2014},
  volume={95 Pt 9},
  pages={
          1983-90
        }
}
We demonstrated previously that immunization with a DNA vaccine expressing the Japanese encephalitis virus (JEV) envelope (E) protein conferred a high level of protection through a poorly neutralizing antibody response. Here, we further investigated the role of the IgG subclass in this antibody-dependent protection using cytokine co-immunization and cytokine-deficient mice. A significant difference in IgG2a/c but not IgG1 was observed between mice that survived or died following a lethal… 
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This suicidal DNA vaccine is a promising candidate facilitating the prevention of DTMUV infection and robust humoral and cellular immune responses were observed in all immunized ducklings.
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