A pooled analysis of vitamin D dose requirements for fracture prevention.

  title={A pooled analysis of vitamin D dose requirements for fracture prevention.},
  author={Heike Annette Bischoff-Ferrari and Walter C. Willett and Endel John Orav and Paul Lips and Pierre Jean Meunier and Ronan A. Lyons and Leon Flicker and John Dennis Wark and Rebecca D. Jackson and Jane A. Cauley and Haakon E. Meyer and Michael Pfeifer and Kerrie M. Sanders and Hannes B. St{\"a}helin and Robert Theiler and Bess Dawson-Hughes},
  journal={The New England journal of medicine},
  volume={367 1},
BACKGROUND The results of meta-analyses examining the relationship between vitamin D supplementation and fracture reduction have been inconsistent. METHODS We pooled participant-level data from 11 double-blind, randomized, controlled trials of oral vitamin D supplementation (daily, weekly, or every 4 months), with or without calcium, as compared with placebo or calcium alone in persons 65 years of age or older. Primary end points were the incidence of hip and any nonvertebral fractures… 

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