A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo.

  title={A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo.},
  author={X. Zhao and S. Ma and N. Liu and Jiakun Liu and W. Wang},
  journal={Carbohydrate polymers},
  • X. Zhao, S. Ma, +2 authors W. Wang
  • Published 2015
  • Chemistry, Medicine
  • Carbohydrate polymers
  • In the present study, we isolated and purified one polysaccharide (TRP) from Trametes robiniophila, which had a backbone of 1,3,6- and 1,4-linked glucpyranosyl moieties, with 1-linked arabinofuranosyl and galactopyranosyl terminal at the O-3 position of 1,3,6-linked glucpyranosyl residues. TRP was further evaluated for its antitumor activity against xenografted U-2 OS osteosarcoma in BALB/c nude mice together with the possible mechanism of action. We found that oral administration of TRP… CONTINUE READING
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