A polymorphism within IL21R confers risk for systemic lupus erythematosus.

  title={A polymorphism within IL21R confers risk for systemic lupus erythematosus.},
  author={R Eric Webb and Joan Tenenbaum Merrill and Jennifer A. Kelly and Andrea L. Sestak and Kenneth M Kaufman and Carl D. Langefeld and Julie T. Ziegler and Robert Kimberly and Jeffrey C. Edberg and Rosalind Ramsey-Goldman and Michelle Petri and John D Reveille and Graciela S Alarc{\'o}n and Luis M Vil{\'a} and Marta E. Alarc{\'o}n-Riquelme and Judith A James and Gary S. Gilkeson and Chaim O. Jacob and Kathy L. Moser and Patrick M Gaffney and Timothy J Vyse and Swapan K. Nath and Peter E Lipsky and John Barker Harley and Amr H. Sawalha},
  journal={Arthritis and rheumatism},
  volume={60 8},
OBJECTIVE Interleukin-21 (IL-21) is a member of the type I cytokine superfamily that has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production. The expression of IL-21 receptor (IL-21R) is reduced in the B cells of patients with systemic lupus erythematosus (SLE), while serum IL-21 levels are increased both in lupus patients and in some murine lupus models. We recently reported that polymorphisms within the IL21 gene… CONTINUE READING


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