A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease.

Abstract

We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio… (More)

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@article{Cooke2006APT, title={A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease.}, author={Graham S Cooke and Kerrie Tosh and Patricia A. Ramaley and Pontiano Kaleebu and Joanna Zhuang and Jessica S Nakiyingi and Christine Watera and Charles F. Gilks and Neil S French and James Whitworth and Adrian V. S. Hill}, journal={The Journal of infectious diseases}, year={2006}, volume={194 5}, pages={666-9} }