A polymorphism of the interleukin-1 beta gene is associated with sperm pathology in humans.

@article{Bentz2007APO,
  title={A polymorphism of the interleukin-1 beta gene is associated with sperm pathology in humans.},
  author={E J Bentz and Lukas Hefler and Dominik Denschlag and Detlef Pietrowski and Bernd Buerkle and Clemens B Tempfer},
  journal={Fertility and sterility},
  year={2007},
  volume={88 3},
  pages={751-3}
}
In a prospective case-control study of 127 normozoospermic and 435 non-normozoospermic Caucasian men, the genotype frequencies of a polymorphism of the interleukin-1 beta gene (IL-1beta Taq C-->T) were statistically significantly different between groups (homozygous wild-type C/C [57%], heterozygous C/T [42%], and homozygous mutant T/T [1%] vs. C/C [57%], C/T [36%], T/T [7%] for normozoospermic and non-normozoospermic men, respectively; odds ratio, 4.8; 95% confidence interval, 1.13 to 20.28… CONTINUE READING

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