A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E ε4 allele

@article{Riemenschneider2002APO,
  title={A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E ε4 allele},
  author={Matthias Riemenschneider and Sandra Schwarz and Stefan Wagenpfeil and Janine Diehl and Ulrich Mueller and Hans F{\"o}rstl and Alexander Kurz},
  journal={Molecular Psychiatry},
  year={2002},
  volume={7},
  pages={782-785}
}
Because of its implication in neuroprotection, formation of long lasting memories and a disturbed function in Alzheimer's disease (AD), brain-derived neurotrophic factor (BDNF) may represent an appropriate candidate gene conferring risk to AD. Recently, a single nucleotide polymorphism (C-270T) within the BDNF gene has been associated with late onset AD in a Japanese population giving an odds ratio (OR) of 3.8. Because of the importance of this finding we analysed the BDNF polymorphism in a… CONTINUE READING

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