A polymorphism linked to RRAS, SCAF1, IRF3 and BCL2L12 genes is associated with cirrhosis in hepatitis C virus carriers.

@article{Real2014APL,
  title={A polymorphism linked to RRAS, SCAF1, IRF3 and BCL2L12 genes is associated with cirrhosis in hepatitis C virus carriers.},
  author={Luis M Real and Antonio Caruz and Antonio Rivero-Juarez and Vicente Soriano and Karin Neukam and Antonio Rivero and Celia C. Cifuentes and Jos{\'e} Antonio Cuenca Mira and Juan Mac{\'i}as and Juan A Pineda},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2014},
  volume={34 4},
  pages={558-66}
}
BACKGROUND & AIMS Host genetic factors could play a primary role in determining risk for cirrhosis development in HCV-infected patients. The aims of this study were to discover new genetic variants associated with this trait and to replicate some associations formerly reported. METHODS Three hundred and thirty-seven HCV carriers with available data about liver fibrosis status, who initiated treatment with pegylated interferon plus ribavirin, were included. Of them, 77 (22.85%) were cirrhotic… CONTINUE READING

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