A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants.

@article{Kostrikis1999API,
  title={A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants.},
  author={Leondios G Kostrikis and Avidan U. Neumann and Brian C. Thomson and Bette T Korber and Patrick McHardy and Rose Karanicolas and Lisa Deutsch and Yaojian Huang and Judy F. Lew and Kenneth Mcintosh and Henry M. Pollack and William Borkowsky and Hans M. L. Spiegel and Paul W. Palumbo and James M. Oleske and K. Cooper and Katherine Luzuriaga and Jayne C. Sullivan and Steven M. Wolinsky and Richard A. Koup and David D. Ho and John P Moore},
  journal={Journal of virology},
  year={1999},
  volume={73 12},
  pages={
          10264-71
        }
}
There are natural mutations in the coding and noncoding regions of the human immunodeficiency virus type 1 (HIV-1) CC-chemokine coreceptor 5 (CCR5) and in the related CCR2 protein (the CCR2-64I mutation). Individuals homozygous for the CCR5-Delta32 allele, which prevents CCR5 expression, strongly resist HIV-1 infection. Several genetic polymorphisms have been identified within the CCR5 5' regulatory region, some of which influence the rate of disease progression in adult AIDS study cohorts. We… CONTINUE READING

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