A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder.

@article{Kim2006API,
  title={A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder.},
  author={C H Kim and Maureen K. Hahn and Yoosook Joung and Susan L Anderson and Angela H Steele and Michelle S Mazei-Robinson and Ian R Gizer and Martin H. Teicher and Bruce M Cohen and David P. Robertson and Irwin D Waldman and Randy D. Blakely and Kwang-Soo Kim},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 50},
  pages={19164-9}
}
The norepinephrine transporter critically regulates both neurotransmission and homeostasis of norepinephrine in the nervous system. In this study, we report a previously uncharacterized and common A/T polymorphism at -3081 upstream of the transcription initiation site of the human norepinephrine transporter gene [solute carrier family 6, member 2 (SLC6A2)]. Using both homologous and heterologous promoter-reporter constructs, we found that the -3081(T) allele significantly decreases promoter… CONTINUE READING
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