A polymorphism in the major gene regulating serum uric acid associates with clinic SBP and the white-coat effect in a family-based study.

@article{Mallamaci2014API,
  title={A polymorphism in the major gene regulating serum uric acid associates with clinic SBP and the white-coat effect in a family-based study.},
  author={Francesca Mallamaci and Alessandra Testa and Daniela Leonardis and Rocco Tripepi and Anna Rita Pisano and Belinda Spoto and Maria Cristina Sanguedolce and Rosa Maria Parlongo and Giovanni Tripepi and Carmine Zoccali},
  journal={Journal of hypertension},
  year={2014},
  volume={32 8},
  pages={
          1621-8; discussion 1628
        }
}
OBJECTIVES Hyperuricemia associates with hypertension, but it is uncertain whether this relationship is causal in nature. Glucose transporter 9 (GLUT9) gene is a major genetic determinant of plasma uric acid levels in humans. Since polymorphisms are randomly distributed at mating (Mendelian randomization), studies based on GLUT9 polymorphisms may provide unconfounded assessment of the nature of the link between uric acid and hypertension. METHODS We tested the association between uric acid… CONTINUE READING
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