A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma.

@article{Niimi2002API,
  title={A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma.},
  author={Tomoaki Niimi and Mitsuru Munakata and Catherine L. Keck-Waggoner and Nicholas C. Popescu and Roy C Levitt and Michie Hisada and Shioko Kimura},
  journal={American journal of human genetics},
  year={2002},
  volume={70 3},
  pages={718-25}
}
Several traits associated with asthma phenotypes, such as high total serum immunoglobulin E and bronchial hyperresponsiveness, have been linked by numerous genome-screen studies and linkage analyses to markers on human chromosome 5q31-q34. In the present article, we describe UGRP1 (encoding uteroglobin-related protein 1) as one of asthma-susceptibility genes that is located on chromosome 5q31-q32. UGRP1 is a homodimeric secretory protein of 17 kDa and is expressed only in lung and trachea. The… CONTINUE READING

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