A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke.

@article{Cipollone2004API,
  title={A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke.},
  author={Francesco Cipollone and Elena Maria Toniato and Stefano Martinotti and Maria Agnese Della Fazia and Annalisa Iezzi and Chiara Cuccurullo and Barbara Pini and Sebastiano Ursi and Gianfranco Vitullo and Maurizio Rocco Averna and Marcello Arca and Anna Montali and Filomena Campagna and Sante Ucchino and Francesco Spigonardo and Stefano Taddei and Agostino Virdis and Giovanni Ciabattoni and Alberto Notarbartolo and Franco Cuccurullo and Andrea Mezzetti},
  journal={JAMA},
  year={2004},
  volume={291 18},
  pages={2221-8}
}
CONTEXT Myocardial infarction (MI) and ischemic stroke are thought to be caused by matrix digestion by metalloproteinases (MMPs) leading to rupture of atherosclerotic plaques. Production of macrophage MMP-2 and MMP-9 is induced by cyclooxygenase 2 (COX-2) and prostaglandin E(2) synthesis. Although COX-2 expression may be genetically determined, the relation between COX-2 polymorphisms and the risk of MI and stroke is unclear. OBJECTIVE To investigate the relationship between the -765G-->C… CONTINUE READING
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