A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.

@article{Ranade2002API,
  title={A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.},
  author={Koustubh Ranade and Eric Jorgenson and Wayne H-H Sheu and Dee Pei and Chao A. Hsiung and Fu-Tien Chiang and Yii-Der I. Chen and Richard L. Pratt and Richard A. Olshen and David Curb and David R. Cox and David Botstein and Neil J. Risch},
  journal={American journal of human genetics},
  year={2002},
  volume={70 4},
  pages={
          935-42
        }
}
  • Koustubh Ranade, Eric Jorgenson, +10 authors Neil J. Risch
  • Published 2002
  • Medicine, Biology
  • American journal of human genetics
  • Resting heart rate is significantly associated with cardiovascular morbidity and mortality. However, the extent to which resting heart rate is genetically determined is poorly understood, and no genes have been found that contribute to variation in resting heart rate. Because signaling through the beta1 adrenergic receptor is a key determinant of cardiac function, we tested whether polymorphisms in this receptor are associated with resting heart rate. A cohort of >1,000 individuals of Chinese… CONTINUE READING

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