A polymorphism in the alpha4 nicotinic receptor gene (Chrna4) modulates enhancement of nicotinic receptor function by ethanol.

@article{Butt2003API,
  title={A polymorphism in the alpha4 nicotinic receptor gene (Chrna4) modulates enhancement of nicotinic receptor function by ethanol.},
  author={Christopher Michael Butt and Scott R Hutton and Jerry A. Stitzel and Seth A. Balogh and James C. Owens and Allan C. Collins},
  journal={Alcoholism, clinical and experimental research},
  year={2003},
  volume={27 5},
  pages={
          733-42
        }
}
BACKGROUND Several studies indicate that ethanol enhances the activity of alpha4beta2 nicotinic acetylcholine receptors (nAChR). Our laboratory has identified a polymorphism in the alpha4 gene that results in the substitution of an alanine (A) for threonine (T) at amino acid position 529 in the second intracellular loop of the alpha4 protein. Mouse strains expressing the A variant have, in general, greater nAChR-mediated 86Rb+ efflux in response to nicotine than strains with the T variant… CONTINUE READING

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Interaction of the nicotinic cholinergic system with ethanol withdrawal.

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