A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin.

@article{Dandrea2005API,
  title={A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin.},
  author={G D'andrea and Rosa Lucia D'Ambrosio and Pasquale Di Perna and Massimiliano Chetta and Rosa Santacroce and Vincenzo Brancaccio and Elvira Grandone and Maurizio Margaglione},
  journal={Blood},
  year={2005},
  volume={105 2},
  pages={
          645-9
        }
}
Patients require different warfarin dosages to achieve the target therapeutic anticoagulation. The variability is largely genetically determined, and it can be only partly explained by genetic variability in the cytochrome CYP2C9 locus. In 147 patients followed from the start of anticoagulation with warfarin, we have investigated whether VKORC1 gene mutations have affected doses of drug prescribed to acquire the target anticoagulation intensity. Two synonymous mutations, 129C>T at Cys43 and… CONTINUE READING
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