A polymorphism in the CTGF promoter region associated with systemic sclerosis.

  title={A polymorphism in the CTGF promoter region associated with systemic sclerosis.},
  author={Carmen Fonseca and Gisela E Lindahl and Markella Ponticos and Piersante Sestini and Elisabetta A Renzoni and Alan Holmes and Paolo Spagnolo and Panagiotis Pantelidis and Patricia Leoni and Neil McHugh and Carmel J. W. Stock and Xu Shi-wen and Christopher P. Denton and Carol Mary Black and Kenneth I. Welsh and Roland M du Bois and David J. Abraham},
  journal={The New England journal of medicine},
  volume={357 12},
BACKGROUND Systemic sclerosis (scleroderma) is a life-threatening autoimmune disease that is characterized by the presence of specific autoantibodies and fibrosis of the skin and major internal organs. METHODS We genotyped a polymorphism (G-945C) in the promoter of the connective-tissue growth factor (CTGF) gene in 1000 subjects in two groups: group 1, consisting of 200 patients with systemic sclerosis and 188 control subjects; and group 2, consisting of 300 patients with systemic sclerosis… CONTINUE READING


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