A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population.

@article{Horikoshi2006API,
  title={A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population.},
  author={Momoko Horikoshi and Kazuo Hara and Jun Ohashi and Kazuaki Miyake and Katsushi Tokunaga and Chikako Ito and Masato Kasuga and Ryozo Nagai and Takashi Kadowaki},
  journal={Diabetes},
  year={2006},
  volume={55 4},
  pages={919-23}
}
AMP-activated protein kinase (AMPK) acts as a fuel gauge for glucose and lipid metabolism. The gene encoding the alpha2 isoform of the catalytic subunit of AMPK (PRKAA2) is located at one of the Japanese type 2 diabetes loci mapped by our previous genome scan (1p36-32). PRKAA2 is, therefore, a good candidate gene for insulin resistance and type 2 diabetes. We screened all nine exons, their exon-intron boundaries, and the 5' and 3' flanking regions of PRKAA2 to identify single nucleotide… CONTINUE READING
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