A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology.

@article{Blain2006API,
  title={A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology.},
  author={J. Val Blain and Nicole Aumont and Louise Th{\'e}roux and Doris Dea and Judes Poirier},
  journal={The European journal of neuroscience},
  year={2006},
  volume={24 5},
  pages={1245-51}
}
Emerging evidences indicate a role for lipoprotein lipase (LPL) in degenerative states. Genetic variations in the LPL gene were previously associated to lipid imbalance and coronary artery disease (CAD) risk and severity, a condition that shares pathological features with common Alzheimer's disease (AD). To evaluate whether these genetic variations associate with the risk and pathophysiology of common AD, autopsy-confirmed patients (242 controls, 153 AD) were genotyped for a PvuII single… CONTINUE READING
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