A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis

@article{Thuong2007API,
  title={A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis},
  author={Nguyen Thuy Thuong Thuong and Thomas R Hawn and Guy E Thwaites and Tran TH Chau and Nguyễn Thị Ngọc Lan and Hoang Thi Quy and Nguyễn Trọng Hiếu and Alan Aderem and T T Hien and Jj J. Farrar and Sarah J Dunstan},
  journal={Genes and Immunity},
  year={2007},
  volume={8},
  pages={422-428}
}
Tuberculous meningitis (TBM) results from the haematogenous dissemination of Mycobacterium tuberculosis from the lung to the brain. Dissemination is believed to occur early during infection, before the development of adaptive immunity. Toll-like receptor 2 (TLR2) mediates recognition of M. tuberculosis and initiates the innate immune response to infection. We hypothesized that polymorphisms in the TLR2 gene influence bacterial dissemination and the development of TBM. A case–control study was… CONTINUE READING

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