A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.

@article{Pan2006API,
  title={A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.},
  author={Huei-Ju Pan and Diana S. Agate and Benjamin L. King and Michele K. Wu and Steven L Roderick and Edward H. Leiter and David M. Cohen},
  journal={FEBS letters},
  year={2006},
  volume={580 25},
  pages={5953-8}
}
New Zealand obese (NZO/HlLt) male mice develop polygenic diabetes and altered phosphatidylcholine metabolism. The gene encoding phosphatidylcholine transfer protein (PC-TP) is sited within the support interval for Nidd3, a recessive NZO-derived locus on Chromosome 11 identified by prior segregation analysis between NZO/HlLt and NON/Lt. Sequence analysis revealed that the NZO-derived PC-TP contained a non-synonymous point mutation that resulted in an Arg120His substitution, which was shared by… CONTINUE READING
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Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice.

American journal of physiology. Gastrointestinal and liver physiology • 2005
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