A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole

@inproceedings{GarcaCasado2009APA,
  title={A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole},
  author={Zaida Garc{\'i}a-Casado and Angel Guerrero-Zotano and Antonio Llombart-Cussac and Ana Calatrava and Antonio Fern{\'a}ndez-Serra and Amparo Ruiz-Sim{\'o}n and Joaqu{\'i}n Gavil{\'a} and Miguel {\'A}ngel Climent and Sergio M Almenar and Jose Cervera-Deval and Josefina Campos and Carlos Vazquez Albaladejo and Antonio Llombart-Bosch and V Guillem and J{\'o}se Antonio L{\'o}pez-Guerrero},
  booktitle={BMC Cancer},
  year={2009}
}
Aromatase (CYP19A1) regulates estrogen biosynthesis. Polymorphisms in CYP19A1 have been related to the pathogenesis of breast cancer (BC). Inhibition of aromatase with letrozole constitutes the best option for treating estrogen-dependent BC in postmenopausal women. We evaluate a series of polymorphisms of CYP19A1 and their effect on response to neoadjuvant letrozole in early BC. We analyzed 95 consecutive postmenopausal women with stage II-III ER/PgR [+] BC treated with neoadjuvant letrozole… CONTINUE READING

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