A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease.

@article{Conrad2002APG,
  title={A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease.},
  author={Chris Conrad and Cintia Vianna and Melissa J. Freeman and Peter Davies},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 11},
  pages={7751-6}
}
A previously undescribed gene, Saitohin (STH), has been discovered in the intron between exons 9 and 10 of the human tau gene. STH is an intronless gene that encodes a 128-aa protein with no clear homologs. The tissue expression of STH is similar to tau, a gene that is implicated in many neurodegenerative disorders. In humans, a single nucleotide polymorphism that results in an amino acid change (Q7R) has been identified in STH and was used in a case control study. The Q7R polymorphism appears… CONTINUE READING
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