A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7

@article{Knowlton1985APD,
  title={A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7},
  author={Robert G. Knowlton and Odile Cohen-Haguenauer and Nguyen van Cong and Jean Fr{\'e}zal and V. A. Brown and David Barker and Jeffrey C. Braman and James W. Schumm and Lap-chee Tsui and Manuel Buchwald and Helen Donis-Keller},
  journal={Nature},
  year={1985},
  volume={318},
  pages={380-382}
}
Although cystic fibrosis (CF) is among the most common inherited diseases in Caucasian populations1, the basic biochemical defect is not yet known. CF is inherited as an autosomal recessive trait apparently due to mutations in a single gene2–4, whence the efforts made to identify the genetic locus responsible by linkage studies. Two markers have recently been identified that are genetically linked to CF: one is a genetic variation in serum level of activity of the enzyme paraoxonase5, and the… CONTINUE READING

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