A polymeric micelle MRI contrast agent with changeable relaxivity.

  title={A polymeric micelle MRI contrast agent with changeable relaxivity.},
  author={Emiko Nakamura and K. Makino and T. Okano and Tatsuhiro Yamamoto and Masayuki Yokoyama},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={114 3},
Polymeric micelles were formed from cationic polymers (polyallylamine or protamine) and anionic block copolymers (poly(ethylene glycol)-b-poly(aspartic acid) derivative) that bound Gd ions providing high contrasts in Magnetic Resonance Imaging (MRI) by shortening the T(1) longitudinal relaxation time of protons of water. The Gd-binding block copolymer alone showed high relaxivity (T(1)-shortening ability) values from 10 to 11 mol(-1) s(-1), while the polymeric micelles exhibited low relaxivity… CONTINUE READING

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