A polyexponential deconvolution method. Evaluation of the “gastrointestinal bioavailability” and meanin vivo dissolution time of some ibuprofen dosage forms

@article{Gillespie1985APD,
  title={A polyexponential deconvolution method. Evaluation of the “gastrointestinal bioavailability” and meanin vivo dissolution time of some ibuprofen dosage forms},
  author={William R. Gillespie and Peter Veng-Pedersen},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1985},
  volume={13},
  pages={289-307}
}
A new deconvolution algorithm (DCON) suitable for pharmacokinetic applications is presented. It requires that both the impulse and input responses, typically systemic drug levels, be well described by polyexponential equations. DCON has a wider range of applications than an earlier method (DECONV) from which it is derived. A FORTRAN program is provided, making implementation of the technique a simple matter. DCON is demonstrated to evaluate the “GI bioavailability,” defined as the rate and the… CONTINUE READING
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