A polydimethylsiloxane-polycarbonate hybrid microfluidic device capable of generating perpendicular chemical and oxygen gradients for cell culture studies.

@article{Chang2014APH,
  title={A polydimethylsiloxane-polycarbonate hybrid microfluidic device capable of generating perpendicular chemical and oxygen gradients for cell culture studies.},
  author={Chia-Wen Chang and Yung-Ju Cheng and Melissa Tu and Ying-hua Chen and Chien-Chung Peng and Wei-Hao Liao and Yi-Chung Tung},
  journal={Lab on a chip},
  year={2014},
  volume={14 19},
  pages={3762-72}
}
This paper reports a polydimethylsiloxane-polycarbonate (PDMS-PC) hybrid microfluidic device capable of performing cell culture under combinations of chemical and oxygen gradients. The microfluidic device is constructed of two PDMS layers with microfluidic channel patterns separated by a thin PDMS membrane. The top layer contains an embedded PC film and a serpentine channel for a spatially confined oxygen scavenging chemical reaction to generate an oxygen gradient in the bottom layer for cell… CONTINUE READING
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