A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells.

@article{Roitbak2004APM,
  title={A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells.},
  author={Tamara Roitbak and Christopher J. Ward and Peter C. Harris and Robert Bacallao and Scott A Ness and Angela Wandinger-Ness},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 3},
  pages={
          1334-46
        }
}
Autosomal dominant polycystic kidney disease (ADPKD) is typified by the accumulation of fluid-filled cysts and abnormalities in renal epithelial cell function. The disease is principally caused by mutations in the gene encoding polycystin-1, a large basolateral plasma membrane protein expressed in kidney epithelial cells. Our studies reveal that, in normal kidney cells, polycystin-1 forms a complex with the adherens junction protein E-cadherin and its associated catenins, suggesting a role in… CONTINUE READING

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