A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.

@article{Hayashita2005APM,
  title={A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.},
  author={Yoji Hayashita and Hirotaka Osada and Yoshio Tatematsu and Hideki Yamada and Kiyoshi Yanagisawa and Shuta Tomida and Yasushi Yatabe and Katsunobu Kawahara and Yoshitaka S Sekido and Takashi Takahashi},
  journal={Cancer research},
  year={2005},
  volume={65 21},
  pages={9628-32}
}
MicroRNAs (miRNAs) are small noncoding RNAs, thought to be involved in physiologic and developmental processes by negatively regulating expression of target genes. We have previously reported frequent down-regulation of the let-7 miRNA family in lung cancers and, in the present study, assessed alteration in a panel of 19 lung cancer cell lines. As a result, we found for the first time that the miR-17-92 cluster, which comprises seven miRNAs and resides in intron 3 of the C13orf25 gene at 13q31… CONTINUE READING
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