A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis

@article{Gautam1992APP,
  title={A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis},
  author={Anand M. Gautam and Cecelia I. Pearson and Dawn E. Smilek and Lawrence Steinman and Hugh O Mcdevitt},
  journal={The Journal of Experimental Medicine},
  year={1992},
  volume={176},
  pages={605 - 609}
}
The minimum structural requirements for peptide interactions with major histocompatibility complex (MHC) class II molecules and with T cell receptors (TCRs) were examined. In this report we show that substituting alanines at all but five amino acids in the myelin basic protein (MBP) peptide Ac1-11 does not alter its ability to bind A alpha uA beta u (MHC… CONTINUE READING