A poly(ADP-ribose) polymerase haplotype spanning the promoter region confers susceptibility to rheumatoid arthritis.

@article{Pascual2003APP,
  title={A poly(ADP-ribose) polymerase haplotype spanning the promoter region confers susceptibility to rheumatoid arthritis.},
  author={Marı́a Pascual and Miguel {\'A}ngel L{\'o}pez-Nevot and Rafael C{\'a}liz and Miguel A. Ferrer and Alejandro Balsa and Dora Pascual-Salcedo and Javier Mart{\'i}n},
  journal={Arthritis and rheumatism},
  year={2003},
  volume={48 3},
  pages={
          638-41
        }
}
OBJECTIVE To investigate the association of the poly(ADP-ribose) polymerase 1 (PARP-1) gene promoter polymorphism with rheumatoid arthritis (RA) predisposition. METHODS An association study with 213 Spanish RA patients and 242 healthy subjects was carried out to investigate the association of all known PARP-1 gene promoter polymorphisms, i.e., a CA microsatellite repeat, a poly(A)(n), and 3 single point mutations (C410T, C1362T, and G1672A), with disease susceptibility. Additionally, we… CONTINUE READING
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