A polarizing question: do M1 and M2 microglia exist?

@article{Ransohoff2016APQ,
  title={A polarizing question: do M1 and M2 microglia exist?},
  author={R. Ransohoff},
  journal={Nature Neuroscience},
  year={2016},
  volume={19},
  pages={987-991}
}
  • R. Ransohoff
  • Published 2016
  • Psychology, Medicine
  • Nature Neuroscience
  • Microglial research has entered a fertile, dynamic phase characterized by novel technologies including two-photon imaging, whole-genome transcriptomic and epigenomic analysis with complementary bioinformatics, unbiased proteomics, cytometry by time of flight (CyTOF; Fluidigm) cytometry, and complex high-content experimental models including slice culture and zebrafish. Against this vivid background of newly emerging data, investigators will encounter in the microglial research literature a body… CONTINUE READING
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    References

    SHOWING 1-10 OF 70 REFERENCES
    New tools for studying microglia in the mouse and human CNS
    • 740
    • PDF
    The Microglial Sensome Revealed by Direct RNA Sequencing
    • 806
    • PDF
    Brain trauma elicits non-canonical macrophage activation states
    • 69
    • PDF
    Microglia in development: linking brain wiring to brain environment.
    • 81