A polarizing question: do M1 and M2 microglia exist?

  title={A polarizing question: do M1 and M2 microglia exist?},
  author={R. Ransohoff},
  journal={Nature Neuroscience},
  • R. Ransohoff
  • Published 2016
  • Psychology, Medicine
  • Nature Neuroscience
  • Microglial research has entered a fertile, dynamic phase characterized by novel technologies including two-photon imaging, whole-genome transcriptomic and epigenomic analysis with complementary bioinformatics, unbiased proteomics, cytometry by time of flight (CyTOF; Fluidigm) cytometry, and complex high-content experimental models including slice culture and zebrafish. Against this vivid background of newly emerging data, investigators will encounter in the microglial research literature a body… CONTINUE READING
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