A point mutation within CD45 exon A is the cause of variant CD45RA splicing in humans.

@article{Zilch1998APM,
  title={A point mutation within CD45 exon A is the cause of variant CD45RA splicing in humans.},
  author={Christian F. Zilch and Andrew M Walker and Marcos Mart{\'i}n Tim{\'o}n and Lydia Kerkerian-Le Goff and Diana L. Wallace and Peter Beverley},
  journal={European journal of immunology},
  year={1998},
  volume={28 1},
  pages={
          22-9
        }
}
The leukocyte common antigen (CD45) is alternatively spliced, generating various isoforms expressed on hemopoietic cells. The splicing pattern of CD45 in T cells is altered in some individuals who show abnormal expression of high molecular weight isoforms containing exon A. The variant splicing pattern was shown to be associated with heterozygosity for a silent point mutation within CD45 exon A. This C to G transition is located 77 nucleotides downstream of the splice acceptor junction of exon… CONTINUE READING
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