A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.

Abstract

Heterotrimeric G-protein Galpha subunits and GoLoco motif proteins are key members of a conserved set of regulatory proteins that influence invertebrate asymmetric cell division and vertebrate neuroepithelium and epithelial progenitor differentiation. GoLoco motif proteins bind selectively to the inhibitory subclass (Galphai) of Galpha subunits, and thus it… (More)
DOI: 10.1074/jbc.M804936200

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Cite this paper

@article{Willard2008APM, title={A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.}, author={Francis S Willard and Zhen Zheng and Juan Guo and Gregory J. Digby and Adam J. Kimple and Jason M. Conley and Christopher A. Johnston and Dustin E. Bosch and Melinda D. Willard and Val J. Watts and N. Lambert and Stephen R Ikeda and Q. Du and David P. Siderovski}, journal={The Journal of biological chemistry}, year={2008}, volume={283 52}, pages={36698-710} }