A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

@article{Reddy1982APM,
  title={A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene},
  author={E. P. Reddy and Roberta K. Reynolds and Eugenio Santos and Mariano Barbacid},
  journal={Nature},
  year={1982},
  volume={300},
  pages={149-152}
}
The genetic change that leads to the activation of the oncogene in T24 human bladder carcinoma cells is shown to be a single point mutation of guanosine into thymidine. This substitution results in the incorporation of valine instead of glycine as the twelfth amino acid residue of the T24 oncogene-encoded p21 protein. Thus, a single amino acid substitution appears to be sufficient to confer transforming properties on the gene product of the T24 human bladder carcinoma oncogene. 
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