A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

@article{Weiner1989APM,
  title={A point mutation in the neu oncogene mimics ligand induction of receptor aggregation},
  author={David B. Weiner and Jing Liu and Margaret Cicely Langton Greene},
  journal={Nature},
  year={1989},
  volume={339},
  pages={230-231}
}
THE rat neu gene, which encodes a protein closely related to the epidermal growth factor receptor1, is a proto-oncogene that can be converted into an oncogene by a point mutation. Both genes encode proteins with a relative molecular mass of 185,000 but the question of why the neu gene product, p185neu, is oncogenic, whereas the product of c-neu, p185c-neu, is not, remains unanswered. The proteins have several features common to the family of tyrosine kinase growth-factor receptors, including… CONTINUE READING
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