A point mutation in the mma3 gene is responsible for impaired methoxymycolic acid production in Mycobacterium bovis BCG strains obtained after 1927.

@article{Behr2000APM,
  title={A point mutation in the mma3 gene is responsible for impaired methoxymycolic acid production in Mycobacterium bovis BCG strains obtained after 1927.},
  author={Marcel A. Behr and Benjamin G Schroeder and Jacquelyn N. Brinkman and Richard A. Slayden and Clifton E Barry},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 12},
  pages={3394-9}
}
BCG vaccines are substrains of Mycobacterium bovis derived by attenuation in vitro. After the original attenuation (1908 to 1921), BCG strains were maintained by serial propagation in different BCG laboratories (1921 to 1961). As a result, various BCG substrains developed which are now known to differ in a number of genetic and phenotypic properties. However, to date, none of these differences has permitted a direct phenotype-genotype link. Since BCG strains differ in their abilities to… CONTINUE READING

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