A point mutation in the Sendai virus accessory C proteins attenuates virulence for mice, but not virus growth in cell culture.

@article{Garcin1997APM,
  title={A point mutation in the Sendai virus accessory C proteins attenuates virulence for mice, but not virus growth in cell culture.},
  author={Dominique Garcin and Masae Itoh and Daniel Kolakofsky},
  journal={Virology},
  year={1997},
  volume={238 2},
  pages={424-31}
}
A mutant Sendai virus (SevMVC), which grows much better than its progenitor virus (SeVM) in cell culture, but, in strong contrast to SeVM, is totally avirulent for mice, has been described. SeVMVC contains two amino acid substitutions relative to SeVM, namely, F170S in the C protein and E2050A in the L protein. We have examined which substitutions were responsible for the above phenotypes by exchanging the C gene of our reference strain Z with those of SeVH (another reference strain), SeVM, and… CONTINUE READING

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