A point mutation in a Drosophila GABA receptor confers insecticide resistance

@article{ffrenchConstant1993APM,
  title={A point mutation in a Drosophila GABA receptor confers insecticide resistance},
  author={Richard H. ffrench-Constant and Thomas A. Rocheleau and J. C. Steichen and Alison E. Chalmers},
  journal={Nature},
  year={1993},
  volume={363},
  pages={449-451}
}
VERTEBRATES and invertebrates both have GABA (γ-aminobutyric acid) as a major inhibitory neurotransmitter1,2. GABAA receptors in vertebrates assemble as heteromultimers to form an integral chloride ion channel3. These receptors are targets for drugs and pesticides4 and are also implicated in seizure-related diseases5,6. Picrotoxinin (PTX) and cyclodiene insecticides are GABAA receptor antagonists which competitively displace each other from the same binding site7. Insects8 and vertebrates9… 
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