A point mutant of human sphingosine kinase 1 with increased catalytic activity.

Abstract

Sphingosine kinase (SK) catalyses the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in mediating such fundamental biological processes as cell growth and survival. Very little is currently known regarding the structure or mechanisms of catalysis and activation of SK. Here we have tested the functional importance of… (More)

Topics

Cite this paper

@article{Pitson2001APM, title={A point mutant of human sphingosine kinase 1 with increased catalytic activity.}, author={Stuart M Pitson and Policarpo Moretti and Julia R. Zebol and Mathew A. Vadas and R. D'Andrea and Binks W. Wattenberg}, journal={FEBS letters}, year={2001}, volume={509 2}, pages={169-73} }