A pleiotropic defect reducing drug accumulation in cisplatin-resistant cells.

@article{Liang2004APD,
  title={A pleiotropic defect reducing drug accumulation in cisplatin-resistant cells.},
  author={Xing-Jie Liang and D. K. Shen and Michael M. Gottesman},
  journal={Journal of inorganic biochemistry},
  year={2004},
  volume={98 10},
  pages={1599-606}
}
The resistance of tumors to cisplatin remains a major cause of treatment failure in cancer patients. Multiple, simultaneous alterations are frequently encountered in cancer cells selected for cisplatin resistance. To determine whether the complex phenotype results from many different cellular alterations, single-step variants were isolated based on one-step selection in cisplatin. Reduced drug accumulation is a common feature of cisplatin-resistant (CP-r) cancer cells, which is probably caused… CONTINUE READING

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