A platform for compartmentalized protein synthesis: protein translation and translocation in the ER.

@article{Nicchitta2002APF,
  title={A platform for compartmentalized protein synthesis: protein translation and translocation in the ER.},
  author={Christopher V Nicchitta},
  journal={Current opinion in cell biology},
  year={2002},
  volume={14 4},
  pages={412-6}
}
Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the regulation of protein-conducting-channel permeability during membrane protein integration. A hypothesis identifying the endoplasmic reticulum as a site of mRNA localization and… CONTINUE READING

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