A platelet-derived immunoregulatory serum factor with T cell affinity.

  title={A platelet-derived immunoregulatory serum factor with T cell affinity.},
  author={Ira R. Katz and Michael K. Hoffmann and Marjorie B. Zucker and Monica Bell and G. Jeanette Thorbecke},
  journal={Journal of immunology},
  volume={134 5},
A factor in mouse and human serum which enhances immune responses to SRBC and TNP-Ficoll in mice has been described. This factor completely reverses immunosuppression induced by syngeneic lymphoma (RCS) or allogeneic lymph node cells. T lymphocytes bind this factor, since the activity can be removed from serum by absorption with T cell containing spleen cells or cloned cytotoxic T lymphocytes. Furthermore, the factor is active only in the presence of mature T cells. Platelet alpha-granules seem… CONTINUE READING

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