A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms?

@article{Smith2007API,
  title={A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms?},
  author={Glenn E. Smith and V. Shane Pankratz and Selamawit Negash and Mary M. Machulda and Ronald C. Petersen and Bradley F. Boeve and David S. Knopman and John A. Lucas and Tanis J. Ferman and Neil Graff-Radford and Robert J. Ivnik},
  journal={Neurology},
  year={2007},
  volume={69 2},
  pages={133-9}
}
OBJECTIVE To compare logistic and bilogistic models to describe the pattern of cognitive decline in the preclinical phase of Alzheimer disease (AD). METHODS We conducted mixed effects modeling of Mayo Cognitive Factors Scores to determine the longitudinal pattern of cognitive decline in the period 10 years prior to and 5 years following a clinical diagnosis of AD. Our analysis included 199 people that eventually received a diagnosis of clinically probable AD. Participants had at least two… CONTINUE READING

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