A plasmid-borne Rap-Phr system of Bacillus subtilis can mediate cell-density controlled production of extracellular proteases.

@article{Koetje2003APR,
  title={A plasmid-borne Rap-Phr system of Bacillus subtilis can mediate cell-density controlled production of extracellular proteases.},
  author={Emmo J Koetje and Amra Hajdo-Milasinovi{\'c} and Rense Kiewiet and Sierd Bron and Harold 4 Tjalsma},
  journal={Microbiology},
  year={2003},
  volume={149 Pt 1},
  pages={19-28}
}
Bacillus subtilis uses two-component signal transduction systems to sense intra- and extracellular stimuli to adapt to fluctuating environmental situations. Regulator aspartate phosphatases (Raps) have important roles in these processes, as they can dephosphorylate certain response-regulators, and are themselves subject to cell-density-controlled inhibition by secreted Phr (phosphate regulator) peptides. Eleven chromosomal genes encode this family of phosphatases, but in addition, certain… CONTINUE READING

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