A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation


Here we show that plasma kallikrein (PKal) mediates a plasminogen (Plg) cascade in adipocyte differentiation. Ecotin, an inhibitor of serine proteases, inhibits cell-shape change, adipocyte-specific gene expression, and lipid accumulation during adipogenesis in culture. Deficiency of Plg, but not of urokinase or tissue-type plasminogen activator, suppresses… (More)
DOI: 10.1038/35060059


7 Figures and Tables