A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes.

  title={A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes.},
  author={Sibylle Haid and Alexandra Novodomsk{\'a} and Juliane Gentzsch and Christina Grethe and Silvia Geuenich and Dorothea Bankwitz and Patrick Chhatwal and Beate Jannack and Thierry Hennebelle and François Bailleul and Oliver T. Keppler and Marion Poenisch and Ralf Bartenschlager and C{\'e}line Hernandez and Matthieu Lemasson and Arielle R. Rosenberg and Flossie Wong-Staal and Elisabeth Davioud-Charvet and Thomas Pietschmann},
  volume={143 1},
BACKGROUND & AIMS Interferon-based therapies for hepatitis C virus (HCV) infection are limited by side effects and incomplete response rates, particularly among transplant recipients. We screened a library of plant-derived small molecules to identify HCV inhibitors with novel mechanisms. METHODS We isolated phenolic compounds from Marrubium peregrinum L (Lamiaceae). Replication of HCV RNA, virus production, and cell entry were monitored using replicons and infectious HCV. Inhibition of HCV… CONTINUE READING
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