A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages.

@article{Pearson2010APP,
  title={A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages.},
  author={Bret J Pearson and Alejandro S{\'a}nchez Alvarado},
  journal={Development},
  year={2010},
  volume={137 2},
  pages={213-21}
}
The functions of adult stem cells and tumor suppressor genes are known to intersect. However, when and how tumor suppressors function in the lineages produced by adult stem cells is unknown. With a large population of stem cells that can be manipulated and studied in vivo, the freshwater planarian is an ideal system with which to investigate these questions. Here, we focus on the tumor suppressor p53, homologs of which have no known role in stem cell biology in any invertebrate examined thus… CONTINUE READING