A placental growth factor variant unable to recognize vascular endothelial growth factor (VEGF) receptor-1 inhibits VEGF-dependent tumor angiogenesis via heterodimerization.

@article{Tarallo2010APG,
  title={A placental growth factor variant unable to recognize vascular endothelial growth factor (VEGF) receptor-1 inhibits VEGF-dependent tumor angiogenesis via heterodimerization.},
  author={V Tarallo and Loredana Vesci and Onofrio Capasso and Maria Teresa Esposito and Teresa Riccioni and Lucio Pastore and Augusto Orlandi and Claudio Pisano and S De Falco},
  journal={Cancer research},
  year={2010},
  volume={70 5},
  pages={1804-13}
}
Angiogenesis is one of the crucial events for cancer development and growth. Two members of the vascular endothelial growth factor (VEGF) family, VEGF-A and placental growth factor (PlGF), which are able to heterodimerize if coexpressed in the same cell, are both required for pathologic angiogenesis. We have generated a PlGF1 variant, named PlGF1-DE in which the residues Asp72 and Glu73 were substituted with Ala, which is unable to bind and activate VEGF receptor-1 but is still able to… CONTINUE READING