A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2.

@article{Esnault2008APR,
  title={A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2.},
  author={C{\'e}cile Esnault and St{\'e}phane Priet and David Ribet and C{\'e}cile Vernochet and Thomas Bruls and Christian Lavialle and Jean Weissenbach and T. Heidmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 45},
  pages={
          17532-7
        }
}
Syncytin-2 is an envelope gene from the human endogenous retrovirus FRD (HERV-FRD) co-opted by an ancestral primate host, conserved in evolution over >40 Myr, specifically expressed in the placenta, and with a cell-cell fusogenic activity likely contributing to placenta morphogenesis. Here, using the GeneBridge4 human/Chinese hamster radiation hybrid panel, we mapped and identified the human receptor for syncytin-2. This receptor-namely Major Facilitator Superfamily Domain Containing 2 (MFSD2… CONTINUE READING

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